中文摘要：

滤纸经十八烷基三氯硅烷（OTS）疏水化处理以后,用等离子体区域降解滤纸纤维表面的OTS疏水单分子层,使滤纸的局部区域恢复亲水性,得到具有亲疏水图案化的微流控纸芯片.考察了等离子体处理时间对滤纸表面亲水性、亲水深度（水溶液由滤纸表层下渗至内部的纵向深度）的影响.优化模具的设计,依据对滤纸亲水深度的不同需求,设计了两种PMMA-PDMS复合片的组合模具.初步探讨了该亲疏水性变化过程的化学机理.将制得的纸芯片用于人体全血中血糖含量的测定,线性范围为1.7～17.7 mmol·L-1,可满足血液样品中血糖的测定.

英文摘要：

Currently, various methods for fabricating microfluidic paper-based analytical devices （μPADs） have been proposed due to their great potential applications in many fields such as clinical diagnosis, food quality control and environmental monitoring. Hereby, a novel and simple method for the fabrication of microfluidic paper-based analytical devices via plasma treatment is reported. Paper was first hydrophobized via octadecyltrichlorosilane （OTS） silanization. The OTS silanized paper was then region-selectively plasma-treated via a mask with channel network. The plasma-exposed area of the paper was turned to hydrophilic channel network due to the degradation of hydrophobic OTS molecules coupled to the paper＇s cellulose fibres before. Two types of hybrid polymethyylmethacrylate-polydimethylsiloxane （PMMA-PDMS） masks were developed to obtain well defined hydrophilic channel with the required depth. With the elastic PDMS piece adhered to the rigid PMMA piece, it excellently solved the problem of the expansion ofhydrophilic channel caused by the leakage of plasma atmosphere in the gap between the mask and paper. The effect of plasma-treating time on hydrophilicity of paper was investigated. The water contact angle （WCA） dramatically decreased from 133.9°± 1.3° to 0° with the prolonging of the plasma treating time from 0 s to 30 s. Meanwhile, the depth ofwettable channel could also increase to nearly the thickness （180 μm） of the paper after treated for 30 s. Attenuated total reflectance Fourier transformed infrared （ATR-FT-IR） spectrometer and X-ray photoelectron spectroscopy （XPS） were applied to characterize the surface chemistry of paper during silanization and plasma treatment, and the related mechanism was discussed. The fabricated μPAD was applied for detection of plasma glucose in whole blood. After diluted with 2% NaCl by a ratio of 1 ： 4, plasma could be separated from blood cells due to their different mobility in the channel on paper. The separated plasma reached test