中文摘要：

Toll样受体（Toll-likereceptors，TLRs）是存在于机体的一类重要的模式识别受体，在免疫调节、血细胞的增殖和分化、机体的神经系统发育、肠道免疫耐受的调节、内分泌等方面都有着重要的作用。但是任何事物都有两面性，TLRs也不例外。TLRs介导引起的反应对机体还存在着弊端，TLRs的激活与心血管疾病、代谢性疾病、肺部疾病、肿瘤和肠道自身免疫疾病有很密切的关系。

英文摘要：

As we all know, TLRs is a kind of important pattern recognition receptors in the body and play an important role in the natural immunity, cell proliferation and differentiation, nervous system development, the intestinal immune tolerance, and endocrine. But every coin has two sides and TLRs is not exception. The reaction caused by TLRs also participates in pathogenic process, such as metabolic diseases, autoimmune diseases, lung diseases, cancer, and intestinal autoimmune diseases.