中文摘要：

目的：观察健脾化痰、活血通络与补肾壮骨、活血通络两种不同治法对激素性股骨头坏死鸡血脂、血黏度、凝血及纤溶功能的影响,探讨二者防治股骨头坏死的作用机制和效果。方法：将80只来航鸡随机分为正常组、模型组、洛伐他汀组、健脾组和补肾组,除正常组外其余各组动物均胸肌注射甲基氢化泼尼松琥珀酸钠,洛伐他汀组、健脾组和补肾组同时给予相应的药物,并于给药后8周和16周分批静脉采血,测定全血黏度、血浆黏度、红细胞压积、纤维蛋白原、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三脂、血浆纤溶酶原、抗凝血酶Ⅲ、组织型纤溶酶原激活物、活化部分凝血酶时间、凝血酶时间及凝血酶原时间。采血后处死动物,取出双侧股骨头,切片后进行组织学观察。结果：①光镜下组织学观察结果。正常组软骨细胞排列整齐,骨小梁排列规则、致密、饱满,周边可见成骨细胞和少量破骨细胞,未见脂肪细胞增生及肥大;模型组软骨细胞呈簇状肥大,排列不规则,骨小梁变细,部分软骨下骨小梁断裂、分离,骨髓腔内脂肪细胞肥大、增生,可见空骨陷窝;洛伐他汀组骨小梁稀疏,可见空骨陷窝及髓腔内变大的脂肪细胞;健脾组软骨细胞排列整齐,骨小梁排列尚规则、致密,周边可见大量成骨细胞及少量破骨细胞;补肾组骨陷窝较少,髓腔内脂肪细胞零散分布,髓腔内造血细胞较丰富。②空骨陷窝率。8周时各组动物空骨陷窝率比较,差异有统计学意义（F=6.081,P=0.010）。模型组空骨陷窝率高于正常组、洛伐他汀组和健脾组（q=2.273,P=0.029;q=2.550,P=0.015;q=2.830,P=0.007）,模型组与补肾组比较,差异无统计学意义。16周时各组动物空骨陷窝率比较,差异有统计学意义（F=27.910,P=0.000）。模型组高于正常组、健脾组和补肾组（q=6.330,P=0.000;q=3.730,P=0.000;q=4.440,P=0.000）,模型组与?

英文摘要：

Objective：To compare the effects between STRENGTHENING SPLEEN RESOLV PHLEGM combined with ACTIVAT BLOOD DREDGING COLLATERALS and REINFORCING KIDNEY SUPPERS BONE combined with ACTIVAT BLOOD DREDGING COLLATERALS on blood fat,blood viscosity,blood coagulation and fibrinolysis of chickens with steroid-induced necrosis of femoral head（SNFH）,and to explore the mechanism of action and the role of the two methods in the prevention of SNFH.Methods：Eighty leghorn chickens were randomly divided into normal group,model group,lovastatin group,STRENGTHENING SPLEEN（SS）group and REINFORCING KIDNEY（RK）group.Chickens were administrated with pectoral intramuscular injection of methylprednisolone sodium succinate except those in the normal group,and chickens in lovastatin group,SS group and RK group were simultaneously administrated with respective medicine.After 8 and 16 weeks of medication,venous blood was respectively collected from the chickens in batches for detecting the following parameters as whole blood viscosity（ηb）,plasma viscosity（ηp）,hematocrit（HCT）,fibrinogen（FIB）,high density lipoprotein（HDL）,low density lipoprotein（LDL）,cholesterol total（CHOL）,triglyceride（TG）,plasma plasminogen（PLG）,antithrombinⅢ（AT-Ⅲ）,tissue-type plasminogen activator（t-PA）,activated partial thromboplastin time（APTT）,thrombin time（TT）and prothrombin time（PT）.After blood collection,the chickens were executed for fetching out their bilateral femoral heads,which were sectioned for histological observation.Results：1）The results of histological observation under a light microscope：In normal group cartilage cells lined up in order;bone trabeculae were in regular,close and well-stacked arrangement,surrounded by some osteoblasts and a small number of osteoclasts;and no hypertrophic fat cells were found.The following situations were found in model group as tufted hypertrophic cartilage cells arranged irregularly,thin bone trabeculae,fracture and separation of partial bone tr