中文摘要：

目的：检测HtrA2/Omi,X 染色体连锁凋亡抑制剂（X - linked inhibitor of apoptosis,XIAP ）和半胱天冬酶- 3（Caspase-3）在寻常型银屑病（PV ）中的表达.方法：应用免疫组化SA BC 法检测30 例PV 皮损与10 例正常人皮肤中HtrA2/Omi、XIAP 和Caspase-3 的表达,并分析HtrA2/Omi、XIAP 和C aspase- 3 表达之间的相关性.结果：PV 皮损中XIAP 和Caspase-3 阳性细胞数明显高于正常皮肤（P＜0.01）,HtrA2/Omi阳性细胞数与正常皮肤无明显差异（P＞0.05）.Caspase-3 阳性细胞数和XIAP 呈正相关趋势（P＜0.05）,与HtrA2/Omi表达无明显相关性（P＞0.05）.HtrA2/Omi和XIAP 的表达无明显相关性（P＞0.05）.结论：XIAP 和Caspase-3 可能在PV 的发病中起重要作用.

英文摘要：

Objective： To detect the expression of HtrA2/Omi, X - linked inhibitor of apoptosis （XIAP） and Caspase - 3 in psoriatic lesions. Methods： SABC immunohistochemistry was used to detect the expression of HtrA2/ Omi, XIAP and Caspase - 3 in the lesions of 30 patients with psoriasis vuigaris （PV） and 10 healthy volunteers. The correlation of HtrA2/Omi, XIAP and Caspase - 3 was analyzed. Results： Compared to normal skin, the expression of ）GAP and Caspase - 3 were increased in PV lesions （ P 〈 0.01 ）, but no difference was found between HtrA2/Omi and normal skin （ P 〉 0.05）. In psoriatic lesion, the level of Caspase - 3 was positively correlated with ）GAP （ P 〈 0.05）, while there was no significant correlation between the level of Caspase - 3 and HtrA2/Omi （ P 〉 0.05）, and between HtrA2/Omi and ）GAP （ P 〉 0.05）. Conclusion： ）GAP and Caspase- 3 may play an important role in the pathogenesis of psoriasis vulgaris.