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中文摘要：
目的了解德克隆（dechloraneplus,DP）亚慢性接触对大鼠肝脏、脑和肾脏的损害作用,为DP的安全使用提供毒理学依据。方法成年雄性SD大鼠20只,体重180~220 g,随机分为低剂量组（25 mg/kg）、中剂量组（50 mg/kg）、高剂量组（100 mg/kg）和对照组,每组5只。经口灌胃染毒21 d,从大鼠灌胃前至实验结束,进行三次水迷宫实验,每次间隔三周。实验结束后,腹主动脉取血,检测谷丙转氨酶（ALT）、谷草转氨酶（AST）、胆碱酯酶（CHE）、大鼠胱抑素C（Cystatin C）和血尿素氮（BUN）,解剖取肝脏,检测肝细胞膜脂流动性,取脑组织,检测谷胱甘肽（GSH）、丙二醛（MDA）。结果 DP各剂量组与对照组相比上述各项指标差异无统计学意义（P〈0.05）;三次水迷宫实验结果表明,各染毒组与对照组相比大鼠的学习与记忆能力都没有明显下降。结论亚慢性接触DP不会对大鼠肝、脑、肾产生损害作用,也未对大鼠的学习和记忆能力产生影响。
英文摘要：
Objective In order to understand the damage effect of subchronic exposure to DP on rat liver,brain,kidney,to provide the toxicological basis for the safe use of the DP. Methods 20 adult male SD rats under the weight 180 ~ 220 g were randomly divided into low dose group（ 25 mg/kg）,middle dose group（ 50 mg/kg）,high dose group（ 100 mg/kg） and the control group,with 5 rats in each group. The rats exposed for 21 days by gavage,from the rats by gastric gavage until the end of the test. Three times of water maze were done,with each of the two experiments at three week intervals. After the experiment,the blood from the abdominal aorta,alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,cholinesterase（ CHE）,cystatin C and blood urea nitrogen（ BUN） were determined. Anatomied and their livers were removed,and the liver cell membrane lipid fluidity was determined. The brain tissues were got to determine glutathione（ GSH） and malondialdehyde（ MDA）. Results The biochemical indicato display shows no significant difference in each dose group compared with the control group（ P 〈0. 05）. The three times of water maze experiments results show that the ability of learning and memory in each dosage group rats does not significantly decrease. Conclusion DP doesn＇t have damage effect on liver,brain tissue and kidney of rats,and also does not have effect on the ability of learning and memory of rats.
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