近年来研究发现磷酸化蛋白质在生物矿化过程中起着重要的作用,而卵黄高磷蛋白是目前自然界中磷酸化程度最高的蛋白质之一,已有部分研究证明了卵黄高磷蛋白具有矿化调节作用,但关于它调控矿化的活性位点及具体机制还不明确。本文概述了生物矿化发生的环境、矿化原理、矿化过程及矿化调控等内容,对卵黄高磷蛋白调控生物矿化的相关假说及研究进展进行了探讨。
Recent studies have found that phosphoprotein plays a very important role in biomineralization, and phosvitins possess the highest phosphorylation level among all known proteins in eggs. Phosvitin was speculated to possess regulatory effects on biological mineralization according to some previous studies, but the mechanism and active sites for regulation of mineralization are still unclear. This paper gives a brief overview of where, how and why biomineralization occurs and the way biomineralization is regulated. Recent hypotheses regarding the regulation of biomineralization by phosvitin are also discussed.