中文摘要：

目的:探讨三阴乳腺癌术后辅以剂量密集化疗的临床疗效。方法：选取2004年6月至2010年1月43例三阴乳腺癌患者随机分为治疗组（密集化疗组）和对照组（常规化疗组）。两组患者均采用盐酸吡柔比星(THP)50mg/m4，di，紫杉醇(TAX)ming/m2，d2。密集化疗组每14d重复，而对照组每21d重复。共6个周期。两组患者化疗结束后均给予患侧胸壁及同侧锁骨上放疗DT总=50Gy/(25f.5w)。结果:全部病例均按计划完成治疗,并随访60个月以上,随访率97.7%。密集化疗组与常规治疗组的3年无病生存率分别为60.9%和30.0%(P<0.05)。两组3年总生存率分别为78.0%和65.0%(P>0.05)。密集化疗组和常规化疗组的5年无病生存率及5年总生存率分别为13.0%、10.0%(P>0.05)和39.丨％、30.0%(P>0.05)。但密集化疗组的无病生存期（DFS)为11~28个月，中位无病生存期（MDFS)为23.4个月，较常规化疗组无病生存期（10~25个月）及中位无病生存期（20.6个月）明显延长。两组在胃肠道反应、骨髓抑制及心脏毒性等毒副反应方面的发生率分别为47.8%、65.2%、47.8%和45.0%、55.0%、40.0%,均无显著性差异（P>0.05)。两组均无n-IV度胃肠道反应及心脏毒性。结论:三阴乳腺癌术后辅以密集化疗能有效提高患者3年无病生存率,延长患者无病生存期，且相关毒副反应未明显增加。

英文摘要：

Objective: To evaluate the clinical efficacy of dose - dense chemotherapy in the postoperative treatment of triple - negative breast cancer. Methods : All 43 patients were enrolled. The patients were divided into two groups at random. The dose - dense group was treated with THP 50mg/m2 ,dl ,TAX 175mg/m2 ,d2, repeated every 14 days. The conventional group was treated with THP 50mg/m2 ,dl ,TAX 175mg/m2 ,d2,repeated every 21 days. Both with a total treatment of 6 cycles. All patients accepted breast and supraclavicular radiotherapy reach to DT =50Gy/(25f ? 5w) after 6 cycles of chemotherapy. Results:All 43 patients completed treatment as planned. All patients were followed - up for more than 60 months,with a follow - up rate 97.1% . The three years disease free survival rate was 60. 9% and 30. 0% (P <0. 05) in dose - dense group and conventional group. The three years total survival rates were 78. 0% and 65. 0% ( P > 0. 05 ). The five years disease free survival rate was 13. 0% and 10. 0% ( P > 0. 05 ) in dose - dense group and conventional group. The five years total survival rate was 39. 0% and 30. 0% ( P > 0. 05 ) in two groups.But the DFS of the dose - dense group was longer than the conventional group. The adverse effect of gastrointestine , arrest of marrow and cardiac toxicity was no significant difference between dose - dense group (47. 8% ,65. 2% ,47. 8% ) and conventional group (45. 0% ,55.0% ,40. 0% ). There was no HI.一 IV.adverse effect of gastrointestine and cardiac toxicity in all patients. Conclusion : The dose - dense chemotherapy in the postoperative treatment of triple -negative breast cancer can prolong the MDFS and effectively improve the three years disease free survival rate,with tolerable toxicity