中文摘要：

通过滴定法研究吲哚美辛在自乳化处方中的相行为，利用多元线性回归（MLR）与人工神经网络（ANN）分别建立自乳化面积与处方中各组分的分子描述符（如量子化学参数、物理化学参数和分子拓扑学参数）之间的定量构效关系（QSAR）模型。研究表明，MLR模型与ANN模型对处方自乳化面积均具有较好的预测能力，且MLR模型的预测能力优于ANN模型。通过油相、乳化剂等组分的分子结构计算其在系统中的白乳化能力，有助于进行处方筛选，提示利用计算的方法可提高试验效率。

英文摘要：

Titration method was used for the research on the phase behavior of indomethacin-contained self- emulsifying drug delivery system （SEDDS）. The quantitative structure-activity relationship （QSAR） models were established to describe the correlation between the molecular descriptors, such as quantum chemical, physical chemical and topological parameters, of the components and the self-emulsifying region of SEDDS loaded with indomethacin by multiple linear regression （MLR） and artificial neural network （ANN）. The results demonstrated that both models showed good predictive ability, and MLR model was superior to ANN model. The self-emulsification capability of oil and surfactants would be calculated from their molecular descriptors, which might guide for screening the optimal formulation.