中文摘要：

瞄准：为了证实胰岛素是否调整，在 3T3-L1 preadipocytes 的区别和关系期间在表示和分泌物抵抗抵抗在与抗胰岛素性在活体内和在试管内。方法：上层清液抵抗在在 3T3-L1 preadipocytes 的区别期间被测量。L6 老鼠 myoblasts 和肝细胞瘤房间线 H4IIE 被用来证实细胞的功能抵抗在里面。导致食谱的肥胖的老鼠被用作一个抗胰岛素性模型学习关系抵抗在与抗胰岛素性。结果：抵抗素表示和分泌物在区别 3T3-L1 preadipocytes 期间被提高。刺激的这细胞的区别在表示和分泌物抵抗，但是被胰岛素压制。抵抗素也在 H4IIE hepatocytes 和 L6 myoblasts 导致了抗胰岛素性。在导致食谱的肥胖的老鼠，浆液在层次抵抗否定地与胰岛素敏感度，然而并非与浆液胰岛素被相关。结论：胰岛素能禁止在表示和分泌物抵抗在试管内，而是胰岛素不是一个主要管理者在在活体内抵抗。胖织物质量由改变表示和分泌物影响胰岛素敏感度抵抗在里面。

英文摘要：

AIM： To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro. METHODS： Supernatant resistin was measured during differentiation of 3T3-L1 preadipocytes. L6 rat myoblasts and hepatoma cell line H4IIE were used to confirm the cellular function of resistin. Diet-induced obese rats were used as an insulin resistance model to study the relationship of resistin with insulin resistance. RESULTS： Resistin expression and secretion were enhanced during differentiation 3T3-L1 preadipocytes. This cellular differentiation stimulated resistin expression and secretion, but was suppressed by insulin. Resistin also induced insulin resistance in H4IIE hepatocytes and L6 myoblasts. In diet-induced obese rats, serum resistin levels were negatively correlated with insulin sensitivity, but not with serum insulin. CONCLUSION： Insulin can inhibit resistin expression and secretion in vitro, but insulin is not a major regulator of resistin in vivo. Fat tissue mass affects insulin sensitivity by altering the expression and secretion of resistin.