中文摘要：

从软联系珊瑚的放射菌类紧张的寡营养的文化， Streptomyces sp。 OUCMDZ-1703 ，我们孤立并且识别我们把 strepchloritides 称为 A 和 B ( 1 和 2 )的二新使氯化的 polyketides ，作为 watasemycin A ( 3 )知道的三 thiazole 衍生物， pulicatin G ( 4 )和 aerugine ( 5 )与 pyrrole-2-carboxamide 一起， furan-2-carboxamide 和1-( 3,5-dihydroxyphenyl ) ethanone 。1 和 2 的新结构被象 1D-NMR 和 2D-NMR 和 MS 分析那样的分光镜的研究决定，当已知的混合物被 NMR 数据的比较在文学与那些识别时。结果证明放射菌类种类 OUCMDZ-1703 能在寡营养的媒介使用氯的相对高比率综合使氯化的自然产品。新混合物 1 和 2 与 9.9 和 20.2 的 IC50 价值对 MCF-7 房间显示了 cytotoxicity ?? 愠杮' 讙贅 H 敮 ???????? 寓？？

英文摘要：

From the oligotrophic culture of a soft coral-associated actinomycetes strain, Streptomyces sp. OUCMDZ-1703, we isolated and identified two new chlorinated polyketides that we named strepchloritides A and B （1 and 2）, three thiazole derivatives known as watasemycin A （3）, pulicatin G （4） and aerugine （5）, along with pyrrole- 2-carboxamide, furan-2-carboxamide and 1-（3,5-dihydroxyphenyl）ethanone. The new structures of 1 and 2 were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. The results showed that actinomycete strain OUCMDZ-1703 could use the relative high ratio of chlorine in the oligotrophic medium to synthesize chlorinated natural products. New compounds 1 and 2 displayed cytotoxicity against the MCF-7 ceils with ICs0 values of 9.9 and 20.2 ~tmoloL-1, respectively. Thiazole derivatives 3 and 5 were first found to be active against three clinical strains of methicillin-resistant Staphylococcus aureus （MRSA082, MRSA111 and MRSA234） with the same MIC/MBC values of 7.81/7.81 μg·mL-1.