中文摘要：

目的 为高强度聚焦超声（HIFU）治疗所引起的软组织损伤提供一种超声监控成像方法。方法 将超声背向散射积分（IB）参量成像与数字减影法相结合，提出IB减影成像方法用于HIFU治疗的损伤区域监控成像。结果 获得了离体牛肉和牛肝组织的IB减影图像及相应的B超图像和衰减系数减影图像，并得到不同阈值和频谱计算窗宽下的IB减影图像。结论 IB减影成像方法能够较有效地对HIFU引起的软组织损伤进行成像，并能检测到B超成像不能检测到的非空化性组织损伤，且其对比度和分辨率均高于衰减系数减影成像。

英文摘要：

Objective To present a method of ultrasonic monitoring imaging for the characterization of lesions in soft tissue induced by high intensity focused ultrasound （HIFU）. Method Differential integrated backscatter （IB） imaging technique were used to monitor the HIFU-induced lesions, which combined IB parameter imaging with the digital differential method, Result The experiments of bovine muscle and liver in vitro were implemented. The differential IB images were acquired as well as the corresponding B-mode images and the differential attenuation images. The differential IB images in various thresholds and calculation window sizes for spectrum analysis were also acquired. Conclusion The differential IB imaging can characterize the HIFU-induced lesions in soft tissue effectively. It can identify the non-cavitation lesions, which can not be detected in B-mode images and offer higher contrast and resolution than that of the differential attenuation images.