中文摘要：

瞬时弹性（Transient Elastography,TE）成像广泛应用于肝硬化研究。然而,在临床应用中,对于肥胖病人,该方法很难实现对深度位置的瞬时剪切波进行检测。研究了将超声编码激励应用于瞬时弹性成像剪切波检测的可行性,选用7位巴克码进行编码检测研究。通过剪切波信噪比和检测穿透力两个指标对编码检测与传统短脉冲检测结果进行量化和对比。弹性仿体实验表明,编码检测可以提供比传统短脉冲检测更高的剪切波信噪比和检测深度。离体猪肝实验表明将编码激励应用于组织检测时同样可以实现高信噪比剪切波检测。这些结果表明编码检测应用于瞬时弹性成像检测是可行的,可以增加其检测深度。

英文摘要：

Transient elastography（TE） is well adapted for use in studying liver elasticity. However, in clinical application, it is challenging to detect the transient shear wave motion in a severe noise environment, such as within deep tissues and for obese patients. This paper, therefore, investigates the feasibility of implementing coded excitation in TE for shear wave detection. The 7 bit Barker code is used in this study. The performances of coded excitation for transient elastography are quantitatively compared in terms of shear wave SNR and the detection depth. Elastic phantom experiment shows that coded pulse outperform traditional short pulse by providing superior shear wave SNR and detection depth. Results from the in vitro liver experiment prove the feasibility of implementing the coding technique in tissue and shows that the coded pulses could provide higher shear wave SNR than the traditional short pulse. These promising results prove the feasibility of implementing coded excitation in TE application, to facilitate superior detection depth.