中文摘要：

目的探讨环境因素对新疆和田地区吐沙拉乡2型糖尿病（T2DM）和高血压的检出率及危险因素的影响,研究转录因子（TCF7L2）与维吾尔族2型糖尿病的相关性。方法在和田吐沙拉乡进行关于T2DM和高血压的流行病学调查,信息录入数据库进行对比。采用PCR技术,对被筛选出的维族样本的5个单核苷酸的多态性（SNP）基因型中的TCF7L2及等位基因频率在糖耐量正常人群和T2DM患者中进行分析。结果 TCF7L2被选SNP的G等位基因和T等位基因在T2DM组和正常糖耐量（NGT）组之间的分布频率差异有统计学意义。GT＆TT和GG的基因型在T2DM组和NGT组之间的分布频率差异也具有统计学意义。结论转录因子7L2（TCF7L2）与和田地区维吾尔族T2DM的发病有一定相关性。

英文摘要：

Objective To study detection rate and risk factors about type 2 diabetes mellitus and hypertension in Tusala town Hetian city,make clear the detection rate＇s contrast between Uygurs and Kazaks.To distinguish which SNPT＇s allele will be put in one group,as them on the same pathway about T2DM happened or not.Methods Enter the epidemiology investigation messages in computer,which from Tusala town Hetian city.PCR was used to analyze five SNP,principal component analysis and cluster analysis were used on data handling.Results There was differences between the allele gene G and T of the chosen SNP.The locate rate of gene GTTT and GG had significant differences.Conclusion The factor of environment effects detection rate and risk factors about type 2 diabetes mellitus and hypertension in Tusala town Hetian city.