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中文摘要：
以硫磺素T为母体,合成和表征了一种苯并噻唑类双功能荧光螯合剂ZY5,并考察了它与金属-Aβ（amyloid-β）聚集体的相互作用。结果表明：ZY5的荧光强度在p H 4.0~10.0的范围内基本稳定,基本不受时间和光照的影响。ZY5符合严格的Lipinski类药标准,能识别和解聚金属-Aβ42聚集体,在一定程度上可抑制由Cu-Aβ42聚集体产生的毒性。
英文摘要：
A thioflavin T -based bifunctional fluorescent chelator ZY5 was synthesized and characterized, its interaction with metal - Aβ（ amyloid - [5） aggregates was also investigated. The results showed that the fluo- rescent intensity of ZY5 was almost stable in the range of pH value from 4.0 to 10.0, and it was hardly affect- ed by time and light. ZY5 fulfilled strict drug - like criteria, and it can recognize and disaggregate metal - Aβ42 aggregates. The cytotoxicity of the Cu - Aβ42 aggregates could be inhibited by ZY5 to some extent.
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