中文摘要：

目的探讨西藏拉萨与那曲地区藏族青少年血清骨碱性磷酸酶（BAP）和骨钙素（OC）的特点及其差异。方法选取拉萨和那曲地区12～18岁健康藏族青少年共1458人，测定身高及血清BAP的活性及OC的含量。结果拉萨男性血清BAP、OC在13～14岁均出现高峰；女性12岁时值最高。而那曲地区男女性血清BAP、OC水平在大部分年龄组明显低于拉萨男女性（P〈0．05）。男性BAP、OC出现高峰的年龄提前1年。2组随年龄增大，血清BAP、OC值均明显下降（P〈0．05）。但拉萨女性在16岁以后，那曲男性16岁以后、女性15岁以后，各年龄组血清BAP、OC水平差异无统计学意义（P〉0．05）。血清BAP、OC水平均与身高密切相关（r=0．42。0．41，P〈0．01）。结论拉萨与那曲藏族青少年男女血清BAP和OC水平均与年龄、性别呈显著相关。但那曲地区青少年BAP和OC水平均低于拉萨地区青少年，且高峰期提前，高水平持续时间短，可能是该地区身高较矮的原因之一。

英文摘要：

Objective To study the characteristics and differences of serum bone alkaline phosphatase（BAP）and osteocalcin（OC） in tibetan adolescents living on Lhasa and Naqu. Methods 1 458 healthy tibetan adolescents in Lhasa and Naqu aged 12-18 were selected in the study. Their height and the levels of BAP, OC were tested. Results The values of serum BAP,OC reached the peak occurring in Lhasa boys at 13 - 14 years old and girls at 12 years. The levels of BAP, OC in Naqu were observably lower than those in Lhasa at mostly age（ P 〈 0.05 ）. BAP, OC levels in Naqu reached peak approximately 1 year earlier, which declined with the increase of age after peak. No significant difference was observed for serum BAP, BGP in Lhasa girls after 16 years old and Naqu boys after 16 and Naqu girls after 15 （P 〉 0.05 ）. Positive correlativity was observed between BAP, OC and height. Conclusion Serum BAP, OC in tibetan adolescent in Lhasa and Naqu are closely associated with age and sex, but the levels were lower, the peak was earlier and persistent time of high level was shorter in Naqu than that in Lhasa. The characteristics of BAP and OC maybe one of the reasons of lower height.