中文摘要：

以前的学习显示出的背景 A 在 PRDM1-ATG5 区域的那 rs548234 多型性在白种人人口与风湿性关节炎(RA ) 被联系。这研究的目的是在中国汉 population.Methods 在危险性上在 PRDM1-ATG5 区域调查 rs548234 多型性的效果到 RA 我们 genotyped 为 rs548234 的 848 个 RA 病人和 1431 匹配的健康控制有 predesigned TaqMan SNP genotyping 试金的单个核苷酸的多型性(SNP ) 。协会分析在整个数据集合上并且在风湿病的因素(RF ) 和反周期的 citrullinated 肽(anti-CCP ) 上被执行抗体。最后，我们基于出版 data.Results 与 RA 执行了 rs548234 协会的联合分析在在为多型性在中国汉人口被发现的 rs548234 ( C/T )的 RA 病人和健康控制之间的遗传型分发的没有重要差别，在整个数据的任何一个也没在成层的子集设定，例如 RF 和 anti-CCP 地位。在不同的种族组的协会分析证明在 PRDM1-ATG5 区域的 rs548234 在白种人祖先与 RA 被联系然而并非在东方亚洲人 population.Conclusions，我们的结果没在中国汉人口在危险性或 RA 的临床的关联在 PRDM1-ATG5 区域显示出 rs548234 的参与。

英文摘要：

Background A previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis （RA） in Caucasian populations. The aim of this study was to investigate the effect of rs548234 polymorphism at PRDM1-ATG5 region on susceptibility to RA in Chinese Han population. Methods We genotyped 848 RA patients and 1431 matched healthy controls for rs548234 single-nucleotide polymorphism （SNP） with a predesigned TaqMan SNP genotyping assay. Association analyses were performed on the whole data set and on rheumatoid factors （RF） and anti-cyclic citrullinated peptides （anti-CCP） antibody. Finally, we carried out combined analysis of rs548234 association with RA based on the published data. Results No significant difference in the genotype distribution between RA patients and healthy controls for rs548234 （C/T） polymorphism was found in Chinese Han population, neither in whole data set nor in stratified subsets, e.g. RF and anti-CCP status. Association analysis in different ethnic groups showed that rs548234 at PRDM1-ATG5 region was associated with RA in Caucasian ancestry but not in East Asian population. Conclusions Our results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population.