中文摘要：

目的 探讨双相障碍患者全血样本基因组 DNA甲基化水平的改变。方法 采用 Illumina 公司人类 450K甲基化芯片分析 10例双相障碍患者和 5名健康对照样本全血基因组 DNA甲基化水平。采用 R软件 minfi包进行数据预处理，应用 R软件 IMA包筛选样本分组间的甲基化位点。采用 GCBI在线分析软件对差异候选基因进行 Gene ontology、Pathway分析。结果 双相障碍患者和对照组相比， SLC6A3、 ARNTL、MAGI2、FAM111A、ZNF578、FAM196A基因甲基化率明显上调，SMPD1、ZEB2、KCNQ5、FAM41C、 RGS18基因甲基化率明显下调。结论 双相障碍与 DNA甲基化水平改变有关。

英文摘要：

Objective To investigate the changes of Genomic DNA methylation from whole bloodsamples in bipolar disorder patients. Methods Genome-wide DNA methylation levels in whole blood ob-tained from 10 bipolar disorder patients and 5 healthy controls were assayed by Infinium Human Methylation450 BeadChip （Illumina）. The association of DNA methylation with bipolar disorder was analyzed by IMA of R project.Gene ontology and Pathway were analyzed by GCBI. Results Compared to healthy controls,DNA methylations of SLC6A3,ARNTL,MAGI2,FAM111A,ZNF578 and FAM196A genes were significantly upregulated,while DNA methylations of SMPD1,ZEB2,KCNQ5,FAM41C and RGS18 genes were significantly downregulated in bipolar disorder patients. Conclusions DNA methylation may be associated with bipolar disorder.