中文摘要：

人组织型激肽释放酶基因（KLK）在多种疾病中发挥着作用,参与体内多种病理生理过程,包括调节血压和水钠代谢,参与炎性反应和心血管保护作用。KLK具有降低血压,改善胰岛素抵抗,抑制心脏和动脉的重构,抑制平滑肌细胞增殖,以及缺血/再灌注损伤的保护作用。KLK可能发挥抗动脉粥样硬化的功效,可能为冠状动脉粥样硬化性心脏病发生的易患基因。该文就KLK与心血管疾病的研究状况予以综述。

英文摘要：

The human tissue kallikrein gene（KLK） plays a role in a variety of diseases,and participates in many pathophysiological processes,including blood pressure regulation and water-sodium metabolism,involved in inflammation and cardiovascular protective effects.KLK has multiple biological effects such as lowering blood pressure,improving insulin resistance,inhibiting cardiac and arterial remodeling,inhibiting smooth muscle cell proliferation,as well as the protective effects of ischemia-reperfusion injury.KLK gene might play anti-atherosclerotic effect,and might be a susceptible gene of coronary heart disease.Here is to make a review of the research status of KLK and cardiovascular disease.