中文摘要：

目的 研究维生素D受体（vitamin D receptor,VDR）和核转录因子（nuclear factor,NF）-κBp65在人结肠癌组织中的表达水平。方法 收集手术切除的结肠癌和对照标本各27例为研究对象,采用免疫组织化学技术检测对照和癌组织VDR和NF-κBp65表达状况。结果 27例结肠癌患者中有5例VDR表达阳性（18.5%）,有7例NF-κBp65表达阳性（25.9%）;对照组有23例VDR表达阳性（85.2%）,有25例NF-κBp65表达阳性（92.6%）。人结肠癌组织VDR和NF-κBp65阳性表达均低于对照组,差异有统计学意义（均有P〈0.001）。结论人结肠癌组织中VDR和NF-κBp65表达呈低水平。

英文摘要：

Objective To explore the expression of vitamin D receptor（VDR） and nuclear factor（NF）-KB p65 in human colon cancer. Methods The expression of VDR and NF-κB in the surgically resected tissue specimens from 27 cases and the normal tissue from 27 people of control were detected by immunohistochemistry. Results The VDR expression of 5 cases （ 18. 5% ） and NF-κB p65 of 7 cases（25.9 % ） was positive in the specimens of 27 cases, but VDR expression of 23 cases （85.2%） and NF-κB p65 of 25 cases（92. 6% ） was positive in the specimens of 27 control. The positive ex- pression of VDR and NF-κB p65 in human colon cancer was lower than that in control （ all P 〈 0. 001 ）. Conclusions The expression of VDR and NF-κB 1365 is low in human colon cancer.