中文摘要：

在过去的十年，河马发信号上的发现揭示了集成各种各样的发信号的小径调制织物动态平衡，机关尺寸控制，织物修理，和新生的一个复杂发信号网络。河马小径失灵与肿瘤和癌症开发被联系。而且，发信号的河马被建议了在许多有机体在众多的干细胞行动。最近，更多的注意被给予了在织物特定的干细胞定义河马小径的功能，它有大潜力在基于房间的治疗被过去常。这里，我们在在相关癌症在上皮的纸巾和它的潜在的含意调整干细胞提供它的角色的概述。

英文摘要：

Over the past decade, discoveries on Hippo signaling have revealed a complex signaling network integrating various signaling pathways to modulate tissue homeostasis, organ size control, tissue repair, and regeneration. Malfunction of the Hippo pathway is associated with tumor and cancer de- velopment. Moreover, Hippo signaling has been proposed to act in numerous stem cells in a variety of organisms. Recently, more attention has been paid to define the functions of the Hippo pathway in tissue-specific stem cells, which have great potential to be used in cell-based therapies. Here we pro- vide an overview of its roles in regulating stem cells in epithelial tissues and its potential implications in related cancers.