欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
碳 nucleophiles 的催化潜力很少向碳 electrophiles 由于他们的反应被揭示了形成稳定的碳碳契约它太强壮，不能为期望的催化周期被劈开。我们开发了羰基混合物的有效催化 cyanosilylation 与一在里面 situ 产生了链烯 / 磷化氢当它的 nucleophilicity 被翻译成催化活动时，使内收，它被调节不在反应条件下面结合羰基混合物或电子缺乏的链烯。面对甲基 acrylate 的 3 mol% 和 triphenylphosphine，大量烷基， alkenyl，和芳基的 3 mol% ，酉同类和醛在房间温度与 trimethylsilyl 氰化物经历 cyanosilylation 反应产出在结构上在优秀收益的多样化的氰醇 silyl 醚。由为羰基混合物的 cyanosilylation 把甲基 acrylate/triphenylphosphine 用作一个高度有效的亲核的催化剂系统，这研究证明为利用链烯 / 磷化氢的 nucleophilicity 的有用 organocatalysis 的发展的一个新概念使内收在 situ 产生了。
英文摘要：
The catalytic potential of carbon nucleophiles has seldom been disclosed due to their reactivity toward carbon electrophiles to form stable carbon-carbon bonds, which are too strong to be cleaved for the expected catalytic cycles. We have developed an efficient catalytic cyanosilylation of carbonyl compounds with an in situ generated alkene/phosphine adduct, which is tuned not to couple with a carbonyl compound or an electron-deficient alkene under the reaction conditions when its nucleophilicity is trans- lated into catalytic activity. In the presence of 3 mol% of methyl acrylate and 3 mol% of triphenylphosphine, a broad range of alkyl, alkenyl, and aryl ketones and aldehydes undergo cyanosilylation reaction with trimethylsilyl cyanide at room temperature to yield structurally diversified cyanohydrin silyl ethers in excellent yields. By using methyl acrylate/triphenylphosphine as a highly effective nucleophilic catalyst system for the cyanosilylation of carbonyl compounds, this study demonstrates a new concept for the development of useful organocatalysis utilizing the nucleophilicity of alkene/phosphine adducts generated in situ.
同期刊论文项目
同项目期刊论文
Controllable stereoselective synthesis of trisubstituted alkenes by a catalytic three-component reac
Selective Benzylic and Allylic Alkylation of Protic Nucleophiles with Sulfonamides through Double Le
Three-component synthesis of amine derivatives using benzylic and allylic alcohols as N-alkylating a
Bronsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enant
Enantioselective concomitant creation of vicinal quaternary stereogenic centers via cyclization of a
Bronsted Acid Catalyzed Dynamic Kinetic Resolution of Azlactones for the Synthesis of Aryl Glycine D
Bronsted acid-catalyzed enantioselective Friedlander condensations: achiral amine promoter plays cru
Catalytic decarboxylative alkylation of beta-keto acids with sulfonamides via the cleavage of carbon
Enantioselective Synthesis of Tetrahydropyrano[3,4-b]indoles Catalyzed by Chiral N-Triflyl Phosphora
Enantioselective Michael/Mannich Polycyclization Cascade of Indolyl Enones Catalyzed by Quinine-Deri
Enantioselective N-Heterocyclic Carbene-Catalyzed Michael Addition to alpha,beta-Unsaturated Aldehyd
Synthesis of (1R,2R)-DPEN-derived triazolium salts and their application in asymmetric intramolecula
Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)a
Catalytic Asymmetric Pictet-Spengler-Type Reaction for the Synthesis of Optically Active Indolo[3,4-
Step-Economical Synthesis of Tetrahydroquinolines by Asymmetric Relay Catalytic Friedlander Condensa
Core-Structure-Oriented Asymmetric Organocatalytic Substitution of 3-Hydroxyoxindoles: Application i
Catalytic Asymmetric Cleavage of sp3 C-N Bonds for Access to Highly Enantioenriched N-Benzylic Sulfo
Kinetic Resolution of Racemic 2,3-Allenoates by Organocatalytic Asymmetric 1,3-Dipolar Cycloaddition
Asymmetric organocatalytic formal double-arylation of azomethines for the synthesis of highly enanti
A Highly Tunable Stereoselective Olefination of Semistabilized Triphenylphosphonium Ylides with N-Su
Byproduct-Catalyzed Four-Component Reactions of Aldehydes with Hexamethyldisilazane, Chloroformates,
Asymmetric intramolecular oxa-Michael addition of activated alpha,beta-unsaturated ketones by chiral
Highly Enantioselective Relay Catalysis in the Three-Component Reaction for Direct Construction of S
Organocatalytic Asymmetric Formal [4+2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3
The role of double hydrogen bonds in asymmetric direct aldol reactions catalyzed by amino amide deri
A Facile and Efficient Approach to N-Protected-b-Sulfinylenamines via C-Sulfinylation of Enamides an
Enantioselective Intramolecular Aza-Michael Additions of Indoles Catalyzed by Chiral Phosphoric Acid
Desymmetrization of Cyclohexadienones via Bronsted Acid-Catalyzed Enantioselective Oxo-Michael React
Catalytic Regioselective Synthesis of Structurally Diverse Indene Derivatives from N-Benzylic Sulfon
ENANTIOSELECTIVE SYNTHESIS OF 2-ARYL-2,3-DIHYDRO-4-QUINOLONES BY CHIRAL BRONSTED ACID CATALYZED INTR
Direct Assembly of Aldehydes, Amino Esters, and Anilines into Chiral Imidazolidines via Bronsted Aci
Organocatalytic asymmetric syn-aldol reactions of aldehydes with long-chain aliphatic ketones on wat
Asymmetric organocatalytic three-component 1,3-dipolar cycloaddition: Control of stereochemistry via
Highly Enantioselective Friedel-Crafts Reaction of 4,7-Dihydroindoles with beta,gamma-Unsaturated al
D-Camphor-derived triazolium salts for catalytic intramolecular crossed aldehyde-ketone benzoin reac
Highly enantioselective Friedel-Crafts reaction of 4,7-dihydroindoles with imines by chiral phosphor
Cooperative catalysis with chiral Bronsted acid-Rh(2)(OAC)(4): Highly enantioselective three-compone
Organocatalytic asymmetric three-component cyclization of cinnamaldehydes and primary amines with 1,
Dual-reagent organocatalysis with a phosphine and electron-deficient alkene: application to the Henr
Organocatalytic asymmetric formal [3+2]cycloaddition reaction of isocyanoesters to nitroolefins lead
Dynamic kinetic asymmetric transfer hydrogenation of racemic 2,4-diaryl-2,3-dihydrobenzo[b][1,4]diaz
Consecutive Intramolecular Hydroamination/Asymmetric Transfer Hydrogenation under Relay Catalysis of
Asymmetric Synthesis of 3-Amino-delta-lactams and Benzo[a]quinolizidines by Catalytic Cyclization Re
An Expeditious Entry to Benzylic and Allylic Sulfones through Byproduct-Catalyzed Reaction of Alcoho
Stereoselective Synthesis of Polysubstituted Alkenes through a Phosphine-Mediated Three-Component Sy
N-Heterocyclic Carbene Catalyzed Ring Expansion of Formylcyclopropanes: Synthesis of 3,4-Dihydro-alp
Methyltrichlorosilane-DMSO: A Facile and Highly Efficient Recipe for the Chlorination of Enamides an
Asymmetric Synthesis of Chiral Oxazolines by Organocatalytic Cyclization of alpha-Aryl Isocyanoester
Catalyst-Free Alkylation of Sulfinic Acids with Sulfonamides via Sp(3) C-N Bond Cleavage at Room Tem
Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/Intramolecular Friedel
Enantioselective Synthesis of Fluorene Derivatives by Chiral Phosphoric Acid Catalyzed Tandem Double
期刊信息
位置：