本文以中医"肺主治节"理论为切入点,在吸收和融合现代生命科学研究成果的基础上,提出了"肺主治节"的内涵与植物神经节后纤维所支配的效应器的生理功能相关,并进一步通过肾上腺素能受体和胆碱能受体的功能探讨,受体激动剂/拮抗剂药物的作用机制和临床用药情况分析,以及治肺中药的药效物质基础解析等方式,来诠释"肺气"的运行与交感及副交感神经功能的相关性。希望通过深入解读"肺主治节"相关理论,旨在发展符合中西医协同创新思想的整合医学,充分发挥中医藏象理论对现代药物研发以及临床疑难疾患治疗的指导作用。
In this paper, Chinese medicine theory about "Fei Qi being responsible for administration and regulation" was carried out as a topic. The modern scientific research achievement had been integrated to propose a hypothesis about the function of "Fei Qi" that related with postganglionic fibers dominated autonomic effector's physiological functions. By analyzing the mechanism and clinical application of adrenergic receptors and cholinergic receptors agonist or antagonist drugs, and summarizing some related effective compounds from traditional Chinese medicine (TCM), we tried to clarify the basic role of "Fei Qi" is checking the balance of yin and yang, which is consistent with sympathetic and parasympathetic nerve regulated functions. After interpreting of modern biological knowledge, we aimed to develop a systematic integrated medicine which fused eastern and western wisdom. Finally, the guiding role of the theory derived from visceral manifestation should be expected fully in the research and development of modern drugs. The application of this theory will be a profound meaning to lead the prevention and clinical treatment for a variety of refractory diseases.