中文摘要：

合成了一种同时含有单偶氮苯基团和双伊环糊精单元的AB2型两亲分子（Azo—CD2），并通过核磁共振谱和基质辅助激光解吸电离飞行时间质谱对其结构进行了表征和确认．动态光散射和透射电子显微镜测试结果表明，在水溶液中，Azo—CD2在无任何外界刺激的条件下可自发地形成球形自组装体，而当施加超声振动后逐渐转变为超分子超支化聚合物自组装体；该自组装体被进一步施加紫外光辐射后可解离成尺寸较小的支化聚集体，而其在可见光辐射下又可以可逆地变回原来的超支化自组装形貌．利用紫外分光光度计测试Azo—CD2自组装体对抗癌药物阿霉素（DOX）的释放曲线发现，通过超声和光的双重调控作用可实现Azo-CD2自组装体对DOX的程序化控制释放．利用一维1H-NMR谱和二维NOESY谱进一步阐明了Azo-CD2自组装体形貌转变过程与其程序化控释结果的相关关系．

英文摘要：

An AB2-type host-guest-conjugated amphiphilic molecule （Azo-CD2） composed of one azobenzene （Azo） and two β-cyclodextrin （β-CD） units was first synthesized through the click reaction of Azo-（N3）2 intermediate containing two azide groups and mono-6-deoxy-6-alkyne β-CD （β-CD-C≡CH） with one alkynyl group. The molecular structure of Azo-CD2 was confirmed by 1H and 13C nuclear magnetic resonances and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The morphology transitions of Azo-CD2 self-assemblies were then investigated by transmission electron microscopy （TEM） and dynamic light scattering （DLS）. Both TEM and DLS results indicated that Azo-CD2 self-assembled into spherical aggregates without external stimuli, and then transformed to bigger supermolecular hyperbranched polymer self-assemblies （SHPS） induced by ultrasound in aqueous solution. These SHPS could be further dissociated into small branched aggregates under UV light irradiation, whereas reverted to supermolecular hyperbranched self-assemblies again by visible light irradiation. By utilizing the above ultrasound and photo-dually tuned self-assembly morphology transition features, a three-stage programmed drug delivery behavior was observed through the cumulative release curves of doxorubicin （DOX）-loaded self-assemblies. Furthermore, the correlativity between self-assembly morphology transitions and programmed drug release was proved by 1H-NMR in D20 and two dimensional nuclear overhauser effect spectroscopy. These results indicated that Azo-CD2 first self-assembled into spherical self-assemblies due to the hydrophilic-hydrophobic interaction, accompanied by a slow release of DOX. And then, the ultrasound stimulus broke the hydrophilic-hydrophobic balance and enhanced the host-guest interaction between β-CD and Azo, further leading to the formation of SHPS with a fast release of DOX. Furthermore, UV light irradiation induced the cis-trans isomerism of Azo and the dissociation of Azo/β