中文摘要：

目的探讨血清铁蛋白在晚期肺癌患者中的表达及临床意义。方法采用电化学发光方法测定69例晚期肺癌患者及63例正常人血清铁蛋白的浓度,分析晚期肺癌患者血清铁蛋白浓度与临床参数及预后的相关性。结果晚期肺癌患者血清铁蛋白浓度高于正常人[（293.57±274.95）ng/ml vs.（145.04±141.77）ng/ml]（P〈0.01）。晚期肺癌患者血清铁蛋白浓度与性别、吸烟与否及淋巴结转移相关（P〈0.05或P〈0.01）,而与年龄、病理学类型、肿瘤部位及远处转移无关（P〉0.05）。与血清铁蛋白正常表达患者相比,血清铁蛋白高表达患者的中位生存时间缩短,死亡风险增加（P〈0.05）。结论检测血清铁蛋白浓度有助于评估判断晚期肺癌患者的病程和预后。

英文摘要：

Objective To investigate the expression and clinical significance of serum ferritin（SF）in the patients with advanced lung cancer.Methods SF expression was detected by electrochemiluminescence method in 69 cases with advanced lung cancer and 63 healthy people.The correlation between SF expression and clinicopathologic parameters and prognosis was analyzed.Results SF expression in the patients with advanced lung cancer was higher than that in healthy people[（293.57±274.95）ng/ml vs.（145.04±141.77）ng/ml]（P〈0.01）.SF expression in the patient with advanced lung cancer was significantly correlated with gender,smoking and lymph node metastasis（P〈0.05 or P〈0.01）,but was not relevant to age,pathological type,tumor location and distant metastasis（P〉0.05）.Moreover,compared with the patients with normal SF expression,the median survival time was decreased and mortality risk was increased in the patients with high SF expression（P〈0.05）.Conclusion Detection of SF expression may contribute to estimating the course and prognosis of patients with advanced lung cancer.