中文摘要：

研究胆固醇酯转运蛋白（CETP）对肝脏B族Ⅰ型清道夫受体（SR—B1）基因表达的影响。结果表明CETP转基因小鼠血清中的总胆固醇（TC）、高密度脂蛋白胆固醇低于对照组，但肝脏内的TC、胆固醇酯却高于对照组（P〈0．05），而两组小鼠血清中的甘油三酯差异无统计学意义；CETP转基因小鼠肝脏SR-B1mRNA表达量均显著低于对照组（P〈0．05）。

英文摘要：

The effect of cholesterol ester transfer protein （CETP） on SR-B1 mRNA expression in mouse liver was investigated. The results demonstrated that CETP transgenic mice showed lower serum total cholesterol and high density lipoprotein-cholesterol levels but higher total cholesterol and cholesterol ester content in liver when compared with wild type mice（P〈0.05 ）. The expression of SR-B1 mRNA in liver of CETP transgenic mice was significantly lower as compared with the control grouP（ P〈0.05 ）.