中文摘要：

ObjectiveThis 学习针对在腹的大动脉的动脉瘤(AAA ) 的致病观察长 noncoding RNA (lncRNAs ) 的角色 AAA 纸巾和正常腹的大动脉的纸巾(NT ) 的 .MethodsLncRNA 和 mRNA 表示签名被 microarray 分析并且进一步由实时量的反向抄写的 PCR (qRT-PCR ) 验证了。指向关系的 lncRNAs-mRNAs 用计算分析被识别。5-lipoxygenase (ALOX5 ) 上的 lnc-ARG 的效果表示在 3,688 lncRNAs 的 HeLa cells.ResultsDifferential 表情被测试， 3,007 mRNAs 在 AAA 和 NT 纸巾之间被识别。而且， 1,284 差别表示了长 intergenic noncoding RNA， 206 差别表示了邻近编码蛋白质的基因的象提高一样 lncRNAs 被生物信息学分析认出。一些差别表示了在 AAA 之间的 lncRNAs 和 mRNAs，正常织物样品是进一步的使用 qRT-PCR 验证。编码和 noncoding 基因的一个合作表示网络基于在差别之间的关联分析被构造表示 lncRNAs 和 mRNAs。另外， lnc-ARG 定位了在以内 ALOX5 在上游被用计算分析分析编码蛋白质的潜力作为一个 noncoding 抄本排序。而且，我们在揭示新 lncRNA 候选人与 AAA 的致病有关的 HeLa cells.ConclusionThis 学习发现那 lnc-ARG 罐头减少 ALOX5 和反应的氧种类生产的 mRNA 水平。

英文摘要：

Objective This study is aimed at observing the role of long noncoding RNAs（lncR NAs） in the pathogenesis of abdominal aortic aneurysm（AAA）.Methods Lnc RNA and m RNA expression signatures of AAA tissues and normal abdominal aortic tissues（NT） were analyzed by microarray and further verified by Real-time quantitative reverse-transcription PCR（q RT-PCR）.The lnc RNAs-m RNAs targeting relationships were identified using computational analysis.The effect of lnc-ARG on 5-lipoxygenase（ALOX5） expression was tested in HeL a cells.Results Differential expressions of 3,688 lncR NAs and 3,007 m RNAs were identified between AAA and NT tissues.Moreover,1,284 differentially expressed long intergenic noncoding RNAs and 206 differentially expressed enhancer-like lnc RNAs adjacent to protein-coding genes were discerned by bioinformatics analysis.Some differentially expressed lncR NAs and m RNAs between AAA and normal tissue samples were further verified using q RT-PCR.A co-expression network of coding and noncoding genes was constructed based on the correlation analysis between the differentially expressed lnc RNAs and mR NAs.In addition,the lnc-ARG located within the upstream of ALOX5 was sorted as a noncoding transcript by analyzing the protein-coding potential using computational analysis.Furthermore,we found that lnc-ARG can decrease the m RNA level of ALOX5 and reactive oxygen species production in He La cells.Conclusion This study revealed new lnc RNA candidates are related to the pathogenesis of AAA.