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稀土药用研究的动向和问题
  • ISSN号：1005-281X
  • 期刊名称：化学进展
  • 时间：0
  • 页码：201-204
  • 语言：中文
  • 分类：R914.3[医药卫生—药物化学;医药卫生—药学]
  • 作者机构：[1]北京大学医学部药学院化学生物学系,北京100083
  • 相关基金：国家自然科学基金项目（No.20637010）和教育部北京大学985项目资助.
  • 相关项目：金属离子通过离子通道途径对线粒体状态的调节
作者： 杨晓达|王夔|杨晓改|
关键词： 稀土, 生物效应, 药物, rare earths, biological effects, therapeutic agents
中文摘要：

人们对稀土药用的兴趣普遍增加。最近Chemical Society Reviews在2006年第6期刊登了镧系元素药用研究专刊，专门介绍稀土药用研究的现状。针对该专刊和稀土药用研究的现状，作者讨论了稀土化合物药用研究的发展动向，特别讨论了需要解决的关键基础问题。从新药研究模式的转变得到启发，提出如何把负面生物效应转化为药理作用，如何从干预细胞信号网络入手进行研究，如何处理活性与毒副作用的关系，以及药物合理设计的策略等。

英文摘要：

The interest on the studies of rare-earths-based drugs is increasing. The recent issue of Chemical Society Reviews is a special issue devoting to the current studies in this aspect. In the present comment, the trends and problems are discussed in connection with the current status in this field and the reviews published in the Chemical Society Reviews. The basic problems open for clarification are emphasized. Enlightened by the changing research paradigm for drug exploration, the following working principles are discussed： to convert the adverse biological effects to the pharmacological ones, to lay the basis of study on the intervention on cell signaling networks, to handle the activitytoxicity relationship and the strategies for rational design.

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金属离子通过离子通道途径对线粒体状态的调节
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稀土元素的生物化学反应和有关细胞化学过程的干预
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期刊信息
  • 《化学进展》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院基础研究局 化学部 文献情报中心
  • 主编：
  • 地址：北京中关村四环西路33号
  • 邮编：100080
  • 邮箱：scinfo@mail.las.ac.cn
  • 电话：010-82627757
  • 国际标准刊号：ISSN：1005-281X
  • 国内统一刊号：ISSN：11-3383/O6
  • 邮发代号:82-645
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）
  • 被引量:21655