中文摘要：

目的探讨细胞周期调控因子D1在大肠癌癌肿组织及肠管近端距肿瘤5cm、10cm组织中的表达及临床意义。方法应用免疫组化（SABC法）检测45例大肠癌癌肿组织及近端肠管距癌灶5cm、10cm的肠管组织中Cyclin D1。结果临床病理因素中,Cyclin D1的表达与肿瘤的分化程度呈反比。有淋巴结转移的大肠癌患者中,大肠癌肿块组织中其Cyclin D1的阳性率为72.2%,无淋巴结转移的大肠癌阳性率分别为44.4%,两者相比差异有显著性（P〈0.05）。Cyclin D1在大肠癌癌肿组织中和距癌灶5cm、10cm的近端肠管的表达,分别为24/45（53.3%）、1/45（2.2%）、0/45（0%）,与后二者相比差异有显著性（P〈0.01,P〈0.01）,以上数据具有统计学意义。结论 Cyclin D1的表达参与了癌细胞分化及发展过程;Cyclin D1在肠管组织中不同距离的表达结果差异显著,可作为大肠癌治疗和预后的辅助性指标之一。

英文摘要：

Objective To study the expression and clinical significance of Cyclin D1 in the colorectal cancer and proximal intestine tissues 5cm and 10cm away from the tumor.Methods To detect the Cyclin D1 in 45 cases of colorectal cancer and intestines 5cm and 10 cm away from the tumor.Results The expression of Cyclin D1 was inversely proportional to the degree of tumor differentiation.The positive rate of Cyclin D1 in patients with lymphatic metastasis and patients without lymphatic metastasis were 72.2% and 44.4% respectively.There were significant differences between the two groups（P0.05）.The positive rate of Cyclin D1 in the colorectal cancer and intestines 5cm and 10cm away from the tumor were 24/45（53.3%）,1/45（2.2%）,and 0/4（0 %） respectively.There were significant differences between the former and the latter two（P0.01,P 0.01）.The above-mentioned data had statistical significance.Conclusions Cyclin D1 participated the differentiation and development of cancer cells;and it had significant difference at different distance from the tumor in intestine tissues.Cyclin D1 can be used as one of the auxiliary indicators in the treatment and prognosis of colorectal cancer.