苝类化合物具有大的共轭体系,易于进行结构修饰,可引入各种功能性基团,这种奇特结构赋予了苝类化合物优良的理化性质和特殊功能,在材料科学、超分子化学、生物、药学、医学等领域具有宽广的应用潜力,尤其在苝类有机光电材料已得到广泛的研究,取得了许多重要成就。尤其是近来越来越多的研究致力于开发苝类化合物其它可能的应用,已延伸到诸多领域,特别是相关生物医药的应用研究已成为近几年来异常活跃的新兴研究领域,引起广泛关注,进展迅速。本文结合课题组的研究工作,参考国内外近五年文献,首次系统地综述了苝类化合物在有机光电材料、纳米材料、生物医药光敏剂、生物荧光标记和成像、药物载体、人工诊断剂、人工离子受体和荧光分子探针等材料、生物、医药领域应用研究新进展。文中注重强化了化合物结构对苝类化合物性质和应用的影响。对未来苝类化合物研究与应用的发展趋势作了展望。
Perylene compounds possess a large π-conjugated system and are easy to be chemically modified by various functional groups. These unique structural characteristics endow with favourable physical and chemical properties as well as special functions, and enable perylene compounds to have a wide range of potential applications in the fields of material science, supramolecular chemistry, biology, pharmacy, medicine and so on. In particular, perylene-based organic photoelectric materials have been widely investigated and many important achievements have been made. More recently, more and more effort has been dedicated to other possible applications of perylene compounds, and the relative research has been expanded to many fields, especially the biomedical research has become an increasingly active emerging field, and attracted wide attention in recent years. Combining with our researches and referring other works from literatures in five years, this paper for the first time systematically reviewed the recent advance in the current research and development of perylene compounds in the fields of material, biological and medical sciences including organic optoelectronic materials, nanomaterials, biomedicinal photosensitizers, fluorescent labeling and imaging agents, drug carriers, artificial diagnostic agents, artificial ion receptors and molecular probes. This review mainly focused on strengthening the effects of structures on properties and applications. At last the perspectives of the foreseeable future are also presented.