中文摘要：

间质性肺疾病（ILD）患者中肺癌的发病率增高，特别是特发性肺纤维化合并肺癌的报道最多。ILD合并肺癌的病理类型以鳞状细胞癌最多，好发于肺下叶和外周部位。ILD的一些肿瘤标记物增高，与疾病的活动程度、严重程度、肺纤维化程度和病情预后等有关，并且具有一定的诊断价值。ILD的肿瘤标记物增高可能是其合并肺癌的危险因素。本文对ILD合并肺癌的流行病学研究和ILD的肿瘤标记物的研究进展做一综述。

英文摘要：

A number of studies have shown a high incidence of lung cancer in patients with interstitial lung disease （ILD）, especially idiopathic pulmonary fibrosis. The most pathological, type of ILD combined with lung cancer is squamous cell carcinoma, and it usually occurs in the lower lobes and peripheral parts. The increase of some tumor markers of ILD is associated with the degree of disease activity, severity, fibrosis, prognosis and so on, and it has a certain diagnostic value. The increase of ILD tumor markers may be the risk factors of ILD combined with lung cancer. This paper makes a review on the epidemiotogieal study of ILD combined with lung cancer and the research progres.＇; of ILD tumor markers.