中文摘要：

血小板是人体中重要的无核血细胞,生理状态下主要发挥止血和促进伤口愈合的作用。此外,血小板也参与了多种病理过程,主要包括炎症、血管生成、组织再生以及肿瘤的恶性发展等。目前,大量研究显示血小板在肿瘤发生发展中发挥着极其重要的作用,并且参与了肿瘤发生发展的多个过程。最新的研究证明肿瘤微环境中血小板RNA水平发生明显改变并且影响着肿瘤的发展进程。该文综述了近几年报道的在肿瘤微环境中肿瘤细胞对血小板RNA影响及其可能产生的病理效应的相关研究。为临床肿瘤检测以及基于RNA进行血小板与肿瘤之间交互作用的研究提供一定指导。

英文摘要：

Platelets are anucleate blood cells best known for their role in hemostasis and wound healing.In addition to hemostasis,platelets are involved in a variety of pathophysiological responses including immune inflammation,angiogenesis,tissue regeneration,and cancer metastasis,and participate in multiple process of tumor development.Recent studies have shown that tumor microenvironment affects the state of RNA in platelets and biology of downstream.This review will focus on our understanding of the possible influence of tumor microenvironment on platelet RNA and the pathological effect,and how this knowledge can guide the development of the interaction between platelets and tumor for clinical application.