中文摘要：

利用高效液相色谱法考察七、八元瓜环对苯丁酸氮芥稳定性的影响.结果表明在37℃,pH 2.0盐酸溶液中,七元瓜环的浓度为2.0×10-4 mol·L-1时可使苯丁酸氮芥的稳定性提高近4倍,而八元瓜环浓度为8.0×10-5 mol·L-1时可使苯丁酸氮芥的稳定性提高近15倍;相溶解度法的研究则证实在苯丁酸氮芥分解速度最低的条件下（3℃,pH 2.0盐酸溶液中）,1.0×10-3 mol·L-1浓度七元瓜环的存在可使苯丁酸氮芥的溶解度增加36倍,八元瓜环浓度为1.0×10-4 mol·L-1时可增加6倍;通过紫外吸收光谱法考察了在不同pH条件下,七、八元瓜环与苯丁酸氮芥的相互作用,计算了瓜环与苯丁酸氮芥相互作用的稳定常数和作用比例,并与动力学的结果进行了比较,同时用核磁进一步验证了瓜环与苯丁酸氮芥的相互作用,给出了可能的相互作用模式.

英文摘要：

The effects of cucurbit（n=7,8）uril（Q） on the solubility and stability of chlorambucil（CHL） have been investigated.The results from high performance liquid chromatography indicated that in the presence of 2.0×10-4 mol.L-1 Q[7],there is a 4-fold increase in the stability of chlorambucil at 37 ℃,pH 2.0,while a greater 15-fold increase in the presence of 8.0×10-5 mol.L-1 Q[8] under same conditions.Aqueous solubility of CHL is increased more than 6-fold or 36-fold increase in the presence of 1.0×10-4 mol.L-1 Q[8] or 1.0×10-3 mol.L-1 Q[7] respectively under conditions where degradation is minimized（3 ℃,pH 2.0）.Stability constants of the CHL complex with Q were determined kinetically and spectro-photometrically under various experimental conditions assuming 1∶1 inclusion complex formation.1H NMR further confirmed that Q could form complexes with CHL and the possible interaction models were proposed.