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基于钯催化的C—H键选择性官能团化构建C—C键
  • ISSN号：1005-281X
  • 期刊名称：《化学进展》
  • 时间：0
  • 分类：O621.36[理学—有机化学;理学—化学] O621.391[理学—有机化学;理学—化学]
  • 作者机构：[1]北京分子科学国家实验室北京大学化学与分子工程学院生物有机与分子工程教育部重点实验室,北京100871, [2]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032
  • 相关基金：国家自然科学基金项目（No.20872104,20832002,20925207和20821062）资助
作者： 李湖[1], 施章杰[1,2]
关键词： 钯催化, C—H键官能团化, 导向, 选择性, 交叉偶联反应, palladium-catalyzed , C-H bonds functionalization , directed , selective , cross-coupling reaction
中文摘要：

近几十年来,钯催化C—H键的选择性官能团化反应已成为有机合成中构建C—C键的重要策略,基本可以分为三类反应模式：C—H键与芳基或烷基卤化物（或拟卤化物）的交叉偶联反应、C—H键之间的交叉脱氢偶联反应、C—H键与金属有机化合物的交叉偶联反应。本文综述了该领域的最新研究进展,介绍了各类反应的特点、优势及在合成中的应用,提出了今后研究和发展的重点及方向。

英文摘要：

In past decades, palladium-catalyzed direct selective C-H bonds functionalization has become a highly attractive strategy in organic synthesis and represents a highly desirable goal. This review introduces three extensively investigated modes for forming C-C bonds from C-H bonds via palladium catalysis： cross-coupling reactions of C-H bonds with aryl or alkyl halides/pseudohalides, cross-dehydrogenative couplings of two C-H bonds, and cross-coupling reactions of C-H bonds with organometallic reagents. A comprehensive summary of recent advances and detailed analysis on the versatility and practicality of these transformations are presented. The research trend for this strategy is also prospected.

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期刊信息
  • 《化学进展》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学院基础研究局 化学部 文献情报中心
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  • 国际标准刊号：ISSN：1005-281X
  • 国内统一刊号：ISSN：11-3383/O6
  • 邮发代号:82-645
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  • 被引量:21655