中文摘要：

目的：研究支气管动脉灌注化疗联合高频热疗治疗晚期非小细胞肺癌的有效性和安全性。方法：选择在本院接受治疗的晚期非小细胞肺癌患者并随机分为两组,观察组接受支气管动脉灌注化疗联合高频热疗,对照组接受支气管动脉灌注化疗。治疗前后分别检测血清中肿瘤活力指标、肝肾功能指标以及肿瘤病灶内增殖、侵袭基因的表达量。结果：治疗后5天、7天时,两组血清中CEA、MIF、CYFRA21-1、HE4的含量均显著低于治疗前且观察组血清中CEA、MIF、CYFRA21-1、HE4的含量显著低于对照组;治疗后7天时,两组肿瘤病灶中MEF2D、c-myc、Survivin、Bcl-2、Vimentin、N-cadherin、Slug的表达量均显著低于治疗前且观察组肿瘤病灶中MEF2D、c-myc、Survivin、Bcl-2、Vimentin、N-cadherin、Slug的表达量显著低于对照组;两组患者治疗前后血清中Scr、BUN、ALT、AST的含量无显著性差异。结论：支气管动脉灌注化疗联合高频热疗治疗晚期非小细胞肺癌能够显著抑制肿瘤的增殖、侵袭且安全性理想。

英文摘要：

Objective：To study the efficacy and safety of bronchial artery perfusion chemotherapy combined with highfrequency hyperthermia for advanced non-small cell lung cancer.Methods：Patients with advanced non-small cell lung cancer who were treated in Navy General Hospital between May 2014 and October 2016 were selected and randomly divided into two groups,the observation group received bronchial arterial infusion chemotherapy combined with high-frequency hyperthermia,and the control group received bronchial arterial infusion chemotherapy.Before and after treatment,the expression of tumor activity indexes and liver and kidney function indexes in serum as well as and proliferation and invasion genes in tumor lesions were detected respectively.Results：Five days and 7dafter treatment,serum CEA,MIF,CYFRA21-1and HE4 levels of both groups of patients were significantly lower than those before treatment and serum CEA,MIF,CYFRA21-1and HE4 levels of observation group were significantly lower than those of control group;7dafter treatment,MEF2 D,c-myc,Survivin,Bcl-2,Vimentin,N-cadherin and Slug expression in tumor lesions of both groups of patients were significantly lower than those before treatment and MEF2 D,c-myc,Survivin,Bcl-2,Vimentin,N-cadherin and Slug expression in tumor lesions of observation group were significantly lower than those of control group;serum Scr,BUN,ALT and AST levels were not significantly different between two groups of patients before and after treatment.Conclusions：Bronchial artery perfusion chemotherapy combined with high-frequency hyperthermia for advanced non-small-cell lung cancer can significantly inhibit the tumor proliferation and invasion and is with ideal safety.