中文摘要：

分别以诺氟沙星初始浓度为10μg·l-1和25mg.l^-1进行氯化消毒实验,用HPLC和SOS/umu遗传毒性测试方法,分别测定不同氯化消毒反应时间后残留诺氟沙星的浓度和遗传毒性,反应速度常数分别为0.0243min^-1和0.0226min^-1;在高浓度反应组,反应45min后反应液的遗传毒性效应有明显的提高,其EC50为131nmol·l^-1,低于反应前的EC50（181nmol·l^-1）,表明在反应过程中生成了遗传毒性高于母体的中间产物.

英文摘要：

chlorination of Norfloxacin at initial concentration of 10 μg ·l^-1 and 25 mg ·l^-1 in clean water at neutral pH conditions were investigated. The Norfloxacin concentrations of aqueous chlorinated solutions during reaction were analyzed using HPLC method to investigate the reaction dynamics. The pseudo-first-order rate constants were determined to be 0. 0243 min^-1 and 0. 0226 min^-1 at initial concentration of 10 μg ·l^-1 and 25 mg ·l^-1, respectively. The genotoxicity of aqueous chlorinated solutions were also determined by a SOS/umu test. The genotoxicity induced by the chlorinated solution at 45 min reaction time when initial concentration of norfloxacin was 25 mg ·l^-1 was obviously higher than that before chlorination of which EC50 was 131 nmol ·l-1, lower than that before chlorination （ 181 nmol ·l^-1 ） , suggesting that some disinfection by-products with higher genotoxicity than the parent were formed during chlorination of norfloxacin.