欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的：探讨大骨节病（Kashin—Beck Disease，KBDt的家族聚集性及其相关的环境因素与遗传因素。方法：采用以人群为基础的病例和对照家系设计，运用条件logistic回归模型对陕西省麟游县212例KBD患者家系和212例对照家系数据进行拟合，以AIC值最小作为判断拟合优度的标准。结果：饮用河水是KBD家庭聚集性的危险因素，饮用自来水是保护因素；父母表型与子女KBD发病相关。结论：KBD的发生是环境因素与遗传因素多种因素作用的结果。饮用河水可能是引起陕西省麟游地区KBD家庭聚集性的主要原因。
英文摘要：
Objective To explore the familial aggregation of Kashin--Beck disease （KBD） and the role of environmental factors and genetic factors in the pathogenesis of KBD. Methods A population--based 1：1 pair matched case-- control family study was conducted. Conditional logistic regressive model was used to fit genealogy of the nuclear families of 212 KBD patients and 212 controls,and the minimum AIC was used to be the standard to determine the goodness of fit. Results Main source of drinking river water was the risk factor of the familial aggregation for KBD,and drinking tap water was protective factor. The phenotype of parents was associated with an increased risk of KBD of children. Conclusion KBD is a multifactorial disease with various enviromnental and genetic factors involved in its etiology,and drinking river water is likely to be a main reason for the familial aggregation of KBD in Linyou county, Shaanxi prov- ince, southwest of China.
同期刊论文项目
同项目期刊论文
Different challenge terms determine disease patterns of antigen-induced pulmonary inflammation in E3
Detection of serum proteomic changes and discovery of serum biomarkers for Kashin-Beck Disease using
Kashin-Beck disease and Sayiwak disease in China: Prevalence and a comparison of the clinical manife
Measuring health-related quality of life in Kashin-Beck disease using EQ-5D. Qual Life Res. 2011;20(
Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and
Suppressive effects of black seed oil on ovalbumin induced acute lung remodeling in E3 rats. Swiss M
Main source of drinking water and familial aggregation of Kashin-Beck disease: a population based on
Oxidant Damage in Kashin-Beck disease and a rat Kashin-Beck disease model by employing T-2 toxin tre
Mitochondrial function is altered in articular chondrocytes of an endemic osteoarthritis, KashineBec
Genome-Wide Gene Expression Analysis Suggests an Important Role of Hypoxia in the Pathogenesis of En
Histopathology of Chondronecrosis development in knee articular cartilage in a rat model of Kashin-B
Correlation analysis between bone mineral density and serum element contents of postmenopausal women
The Relationship between Endothelial Nitric Oxide Synthase Gene Polymorphisms and Osteoporosis in Ch
Morphology and phenotype expression of types I, II, III, and X collagen and MMP-13 of chondrocytes c
Proteomic changes in articular cartilage of human endemic osteoarthritis in China. Proteomics. 2011.
A Modified Method using TRIzol((R)) Reagent and Liquid Nitrogen Produces High-Quality RNA from Rat P
Comparative analysis of gene expression profiles between primary knee osteoarthritis and an osteoart
T-2 toxin induced apoptosis involving NO, P53, Bcl-xL, Bcl-2, Bax and Caspase-3 signaling pathway in
Analysis of correlation between blood biochemical indicators and bone mineral density of post-menopa
High Expression of Liver Histone Deacetylase 3 Deteriorates High-fat-diet-induced Metabolic Syndrome
The effect of short tandem repeat loci and low selenium levels on endemic osteoarthritis in China. J
A systematic comparison between collagen-induced arthritis and pristane-induced arthritis in Dark Ag
Nitric oxide both in bronchoalveolar lavage fluid and serum is assocaited with pathogenesis and seve
Downregulated HS6ST2 in osteoarthritis and Kashin–Beck disease inhibits cell viability and influence
期刊信息
位置：