中文摘要：

目的探讨甲基苯丙胺（methamphetamine,MA）慢性中毒对大鼠肺组织和肺血管的影响以及大鼠肺内5-羟色胺（5-hydroxytryptamine,5-HT）浓度的变化。方法将18只Wistar大鼠随机分成三组：正常对照组、MA低剂量组（5mg/kg）、MA高剂量组（10mg/kg）。采用多导生理记录仪测量血流动力学相关指标,HE染色方法观察肺组织和肺动脉的形态学改变,以及利用ELISA方法检测肺内5-HT浓度的变化。结果与正常对照组相比,MA低剂量组和高剂量组的平均肺动脉压力及右心指数均有增加,但无统计学意义。高剂量MA10mg/kg导致大鼠出现明显肺损伤（P〈0.05）,表现为肺组织炎性细胞浸润,肺泡间隔断裂,肺泡扩张融合,囊腔数量明显减少,肺动脉壁明显增厚,肺动脉中膜厚度百分比明显上升,且肺内5-HT浓度明显升高（P〈0.05）。结论甲基苯丙胺对大鼠肺组织和肺血管有慢性毒性作用,可能与引起肺内5-HT浓度升高有关。

英文摘要：

Objective To investigate the chronic toxic effect of methamphetamine（MA） on the lung parenchyma and pulmonary artery and the 5-HT level in the lung of rats. Methods The eighteen Wistar rats were randomly divided into 3 groups： control group, M5 group （MA 5mg/kg）, and M10 group （MA 10mg/kg）. The hemodynamic measurements were recorded by Polygraph System. Morphological changes of the pulmonary arteries were observed by HE staining. 5-HT level in the lung was detected by ELISA. Results The high dose 10mg/kg of MA induced rat pulmonary toxicity with crowded lung parenchyma, thickened septum, reduced number of alveolar sacs, inflammatory cell infiltration and pulmonary arterial remodeling, and resulted in the significant increase of 5-HT level in the lung. Conclusion The chronic toxic effect of methamphetamine on the lung parenchyma and pulmonary artery was probably associated with the increasing of 5-HT concentration in the lung.