中文摘要：

目的观察中药制剂、免疫调节剂联合化疗与单纯化疗，3种方案治疗复治涂阳肺结核的临床疗效及不良反应。方法将人选患者随机分为中药组105例、免疫组103例和对照组99例，对照组采用3HI2ZV／5HL2V治疗方案，中药组3HL：ZV／5HL：V＋康复新液，免疫组3HL：ZV／5HL：V＋母牛分枝杆菌菌苗。观察治疗3、8个月后的效果，包括痰菌阴转情况、病灶吸收情况、空洞闭合情况、症状改善情况、不良反应情况。结果中药组和免疫组的8个月痰菌阴转率分别为93．3％、92．2％，3个月病灶吸收率为82．9％、78．6％，两项指标与对照组80．8％、50．5％比较，差异具有统计学意义（P〈0．05）。中药组8个月空洞关闭率较对照组差异有统计学意义（P〈0．05）。结论复治肺结核患者采用中药或免疫调节剂联合西药化疗，能够提高机体免疫力，降低不良反应发生率，改善治疗结果，且中药组效果更明显。

英文摘要：

Objective To observe the therapeutic effects and adverse reactions of three therapeutic schemes for treatment of retreatment pulmonary tuberculosis. Methods The patients with retreatment pulmonary tuberculosis were randomly di- vided into three groups. Cases in control group（ n = 99） were treated by a regimen of 3HL2ZV/5HL2V;cases in the TCM group（ n = 105） were treated by a regimen of 3HL2ZV/5HL2V ＋ Kangfuxin liquid;cases in the immunomodulator group （ n = 103 ） were treated by a regimen of 3HL2ZV/5HL2V ＋ Mycobacterium vaccine. The changes were observed at 3 and 8 months after treatment, which were changes of sputum smear from positive to negative, lesions and cavities on radiography. Adverse drug reactions were observed during the whole treatment course. Results The sputum negative conversion rates of three groups at the end of 8 months were 93.3% ,92.2% and 80.8% respectively. The rates of focus absoption at the end of 3 months were 82.9% ,78.6% and 50.5%. Conclusion Combination treatment with TCM or immunomodulator and others for retreatment pulmonary tuberculosis can achieve good results and clinical efficacy,which was worth of being recommended for a wider use in clinical practice.