中文摘要：

目的研究丹参酮ⅡA对大鼠腹腔术后肠黏连的防治作用并测定大鼠血清中IL-1β、tPA、PAI含量的变化。方法构建大鼠肠黏连模型。70只大鼠随机分为假手术组、模型对照组、丹参酮ⅡA高、中、低剂量组、空白溶剂组、阳性对照药组，每组10只；地塞米松组腹腔注射地塞米松5mg／kg，假手术组及模型组给予等量生理盐水，空白溶剂组给予等量不含丹参酮ⅡA的溶剂。各组大鼠于术前1d、术后1、3、5、7d测定血清中IL-1β、tPA和PAI含量。结果高、中、低剂量组、阳性对照药组血清中IL-1β含量显著低于模型对照组、空白溶剂组与假手术组（P〈0．05）；血清中tPA含量显著高于模型对照组、空白溶剂组与假手术组（P〈0．05），PAI含量显著低于模型组和空白溶剂组（P〈0．05），与假手术组相比无显著性差异；高、中、低剂量组、阳性对照药组与模型对照组、空白溶剂组相比，肠黏连程度亦显著性降低（P〈0．001）。结论大鼠腹腔术后腹腔注射丹参酮ⅡA对肠黏连发生有防治作用，其防治作用可能与降低血清中IL-1β、PA1，升高血清中tPA有关。

英文摘要：

Objective To investigate the preventive and therapeutic effect of tanshinone IIA on postoperative intestinal adhesions of rats, and to measure the content of IL--1β, tPA and PAI in serum. Methods The animal models of intestinal adhesions were established. Seventy rats were randomly divided to sham-operated group, model control group, high-, medium-, low-dose group, tanshinone IIA-free group, and positive drug group, and 10 rats in each group. Rats in the positive drug group were injected into the abdominal cavity by dexamethasone, sham-operated group. Rats in the model control group were injected by normal saline, and rats in the tanshinone IIA-free group were injected with equal volume of tanshinone IIA-free solution. The expression of IL--1β, tPA, and PAI in serum were measured at -1, 1, 3, 5, and 7 d. Results The expression of IL-1β in rats of high-, medium-, low-dose group and positive drug group were significantly lower compared with that of the sham-operated group, tanshinone IIA-free group, model control group and tanshinone IIA- free group （P〈0.05）. The expression of tPA were significantly higher than that of the sham-operated group, tanshinone IIA-free group, and model control group （P〈0.05）. The expression of PAI were significantly lower than that of the model control group and tanshinone IIA-free group （P 〈 0.05 ） , but there was no significant difference compared with shamoperated group. Conclusion Tanshinone IIA has preventive and therapeutic effect on postoperative intestinal adhesions and cecum injuries, its mechanism may be related to the decreases of IL-I~ and PAl concentrations in serum, and the increases of tPA in serum.