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中文摘要：
LECT2（leukocyte cell-derived chemotaxin 2）是一个多功能的蛋白质,其与细胞生长、分化、损伤修复及免疫等过程相关。本研究通过设计简并引物,从香鱼肝脏cDNA文库中筛选LECT2基因,该基因cDNA序列全长547个核苷酸,3＇末端具有polyA尾,单一大开读框编码一个由156个氨基酸组成的分子量为17kDa的蛋白质。序列分析及系统进化树分析均表明,香鱼LECT2与虹鳟LECT2最相似,且各物种LECT2的进化关系与目前接受的物种分类关系基本一致。香鱼LECT2基因在香鱼许多组织中均有表达,而肝脏中的表达量最高,肾脏和脑中的表达量也较高。
英文摘要：
Leukocyte cell-derived chemotaxin 2, also known as LECT2, is a protein related with multifunctional roles in cell growth, differentiation, damage/repair process and carcinogenesis to autoimmune diseases. A fulllength cDNA clone of the LECT2 gene, 547 bp in size, 3＇-end with a polyA tail, encoding a protein of 156 amino acids with a molecular weight of 17 kDa, was isolated from the fish ayu （Plecoglossus altivelis）. Sequence comparison and phylogenetic analysis shows that ayu LECT2 （aLECT2） is most similar to rainbow trout LECT2, and the relationships of the different LECT2 coincided well with the evolutionary relationships of their organisms. The mRNA level of aLECT2 was highest in liver and moderately high in kidney and brain.
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