中文摘要：

目的：研究番石榴叶提取物对小鼠肥胖模型的减肥、降脂作用。方法：①利用高脂饲料喂养，建立小鼠肥胖模型；②小鼠肥胖模型初步建立后，以体重、热量摄取、腹部脂肪系数、空腹血糖（FBG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）为指标，通过普通饲料阴性组，阳性对照药非诺贝特给药组比较，探求番石榴叶提取物的减肥、降脂作用及其剂量依赖关系。结果：①与Nomal组比较，HFD组的小鼠体重、热量摄取、腹部脂肪系数、FBG、TG、TC、LDL-C显著增加；②给药后，3个剂量番石榴叶提取物组的小鼠体重、腹部脂肪系数、FBG、TG、TC、LDL-C均明显低于高脂饲料组，且呈显著或极显著差异，并与阳性对照组无明显差异；③3个剂量番石榴叶提取物组的减肥、降脂作用存在一定的效应．剂量关系，即LD组（50mg／Kg）〈MD组（100mg／Kg）〈HD组（200mg／Kg）。结论：番石榴叶60％乙醇提物对小鼠肥胖症和高脂血症有一定的预防和治疗作用，3个剂量组中HD组（200mg/Kg）效果最好，可望开发为减肥降脂的纯天然药物。

英文摘要：

Objective： To investigate the effect of extracts from Psidium guajava leaves on anti-obesity and lipid lowering activity in high-fat diet induced obese mice. Methods： OA model of obesity mice was established by high-fat diet feeding （HFD）. ①The weight, visceral fat accumulation, fasting blood glucose （FBG）, triglyceride （TG）, total cholesterol （TC）, high density lipoprotein （HDL-C） and low density lipoprotein （LDL-C） were measured as indicators to verify the effect of extracts from Psidium guajava leaves on anti-obesity and lipid lowering activity in high-fat diet induced obese mice. The fenofibrate feeding mice were as positive control and normal feeding mice as negative control. Results： ①Compared with the Normal Group, the HFD Group had a significant increase in weight, visceral fat accumulation, FBG, TC, TG and LDL-C. ②After feeding different doses of Psidium gnajava leaves extract, the relevant indicators were significantly down-regulated in each dose, compared with HFD Group, while no significant difference was observed between treatment groups and positive control group. ③ The effect of Psidium guajava leaves extract on anti-obesity and lipid lowering activity was dose-depended, three groups treated with different doses of Psidium guajava leaves extracts, LD Group （50 mg/Kg） 〈 MD Group （100 mg/Kg） 〈 HD Group （200 mg/Kg）. Conclusions： Extracts from Psidium guajava leaves have a preventive and therapeutical effect on obesity and hyperlipidemia of mice and the HD Group （200 mg/Kg） similar to fenofibrate. Thus, extracts from Psidium guajava leaves may be a purely nature drug with anti-obesity and lipid lowering effects.