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高脂饮食中添加短链菊粉对小鼠肠道菌群的影响
  • ISSN号:1673-6273
  • 期刊名称:《现代生物医学进展》
  • 时间:0
  • 分类:TQ657[化学工程—精细化工] S565.01[农业科学—作物学]
  • 作者机构:MOE Key Laboratory of Bioinformatics and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
  • 相关基金:Acknowledgments We thank members of the P.L. Laboratory at Tsinghua University for helpful discussion. This work was supported by the National Basic Research Program (2013CB530602), and the National Natural Science Foundation of China (31430040, 31321003).
中文摘要:

尽管癌症的类型和病原学是不同的,在葡萄糖新陈代谢,戊糖磷酸盐小径(PPP ) 和夫酸安新陈代谢的小径是在癌症细胞的 reprogrammed 适应他们的快速的生长和增长。最近的研究也显示出那多重类脂化合物新陈代谢的小径在癌症房间被改变。这里,我们在癌症开发为丰满的酸新陈代谢的角色向简短评论提供丰满的酸的一个特殊焦点举起和 de novo 合成, triglycerides 合成,存储和降级。在丰满的酸新陈代谢的 Reprogramming 在在癌症开发期间提供精力,为膜合成的大分子和类脂化合物信号起重要作用。理解在癌症房间的新陈代谢的小径将揭示的 deregulated 类脂化合物的机制与癌症作斗争的新奇治疗学的途径。

英文摘要:

Although the type and etiology of cancers are different, pathways in glucose metabolism, pentose phos- phate pathway (PPP) and glutamine metabolism have been reprogrammed in cancer cells to adapt to their rapid growth and proliferation. Recent research has also shown that mul- tiple lipid metabolic pathways are altered in cancer cells. Here, we provide a brief review for the role of fatty acid metabolism in cancer development with a special focus on fatty acid uptake and de novo synthesis, triglycerides syn- thesis, storage and degradation. Reprogramming in fatty acid metabolism plays important roles in providing energy, macromolecules for membrane synthesis and lipid signals during cancer development. Understanding the mechanism of deregulated lipid metabolic pathways in cancer cells would reveal novel therapeutic approaches to combat cancer.

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期刊信息
  • 《现代生物医学进展》
  • 中国科技核心期刊
  • 主管单位:黑龙江省卫生厅
  • 主办单位:黑龙江省红十字医院 黑黑龙江省红十字医院 黑龙江省森林工总医院
  • 主编:申宝忠
  • 地址:哈尔滨市南岗区花园街184号403
  • 邮编:150001
  • 邮箱:biomed_54@126.com
  • 电话:0451-82583800 53658268
  • 国际标准刊号:ISSN:1673-6273
  • 国内统一刊号:ISSN:23-1544/R
  • 邮发代号:14-12
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:33230