This paper focuses on the problem of secure transmission in a cellular system. A full-duplex base station using artificial noise is adopted to improve both the uplink and downlink secrecy rate via pairing terminals which reverses the downlink and uplink of each other. We give the designs of artificial noise and the user’s desired signal, and derive the pairing prin-ciple between terminals. Moreover, the influence of self-interference cancellation on secrecy rate is ex-plored. Simulation results show that the secrecy rate can get much better performance by adopting full-duplex artificial noise scheme and proposed pair-ing method. The downlink secrecy rate decreases with the distance between terminals. Besides the uplink secrecy rate is sensitive to the ability of self-interference cancellation.