中文摘要：

IgA肾病发病机制复杂，病因不明，一些microRNA可能参与其致病过程，并且可能与其关键酶——核心β1、3半乳糖基转移酶相关。现介绍表观遗传学的定义，microRNA的概念、基本结构和功能。结合文献总结、概述目前在IgA肾病患者中已经发现的异常表达的microRNA，以及其可能的作用方式。

英文摘要：

IgA nephropathy is a complex disease with unclear mechanism, microRNAs may involve in the disease,and some of them may be associated with the key enzyme of IgA nephropathy core β1 3-galactosyl- transferase. The concept of epigenetics and the structures and functions of microRNA were introduced. Through revie- wing the related researches, several microRNAs expressing abnormally in IgA nephropathy was found.