欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的：探讨茵陈蒿汤对ANIT急性肝损伤模型的保护作用，并初步探讨其对肝细胞摄取、转化、排泄胆红素的影响，揭示利胆退黄的作用机理，为后续实验建立中医阳黄证黄疸动物模型奠定基础。方法：采用α-异硫氰酸萘酯（ANIT）灌胃诱导大鼠急性肝损伤，观察大鼠ALP，ALT，AST，γ-GT活性及T—BIL，D—BIL，β-G和MDA含量，评价茵陈蒿汤保肝作用。结果：茵陈蒿汤低剂量组能使肝损伤生化指标明显改善，具有显著的保肝作用，而高、中剂量组保肝作用不明显。结论：茵陈蒿汤具有保肝利胆退黄的作用，其机理可能与降低肝细胞β-G、MDA含量，促进胆红素代谢，降低脂质过氧化物含量有关。
同期刊论文项目
同项目期刊论文
Comparative Study on the Protective Effects of Yinchenhao Decoction (sic) against Liver Injury Induc
Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPL
Development of a rapid and validated method for investigating the metabolism of scoparone in rat usi
Hydrolysis of Flavanone Glycosides and Degradation of the Corresponding Aglycones from Dried Immatur
Quality evaluation of Yin Chen Hao Tang extract based on fingerprint chromatogram and simultaneous d
Pharmacokinetics of Cimifugin in Rat Plasma after Oral Administration of the Extract of Saposhnikovi
Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application
Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine
Development and validation of a ultra performance LC-ESI/MS method for analysis of metabolic phenoty
HPLC method for preliminary analysis of constituents in rat blood after oral administration of the e
期刊信息
位置：