中文摘要：

神经胶质瘤是成人最常见的原发性脑肿瘤,可能起源自胶质组织。虽然关于胶质瘤的分子机制和信号通路的认知在过去10年里有很大提高,但高级别胶质瘤仍是预后不良的致命性疾病。目前治疗失败的原因很大程度上与胶质瘤细胞的异质性有关。导致异质性的原因之一是其具有大量遗传变异;而另一个影响因素可能是形成胶质瘤的起源细胞类型。胶质瘤的起源细胞仍未确定,需要更多关于这一问题的知识,才能完整理解神经胶质瘤的生物学特征。通过发育生物学和胶质瘤动物模型的实验研究发现具有形成胶质瘤能力的最可能候选细胞是星形胶质细胞,神经干细胞和少突胶质前体细胞。不同起始细胞类型的胶质瘤,其预后和治疗反应可能会显著不同。因此,有必要深入研究胶质瘤的细胞起源。

英文摘要：

Glioma is the most common primary brain tumor in adults. It may be originated from glial tissue. Although the understanding about molecular mechanisms and signaling pathways of glioma genesis has increased dramatically over the last decades, high grade glioma is still fatal disease with poor prognosis. The reasons for the failure of treatment are largely due to the heterogeneity of glioma cells. One reason for this heterogeneity is that high grade glioma has a large number of genetic variation. Another factor affecting the heterogeneity of glioma may be the origin cells from which gliomas take place. The origin of glioma cells have not been identified, more knowledge about this problem are needed to completely understand glioma biology. Based on developmental biology and experimental glioma model, the most likely candidate cells may be astrocytes, neural stem cells, andoligodendrocyte precursor cells. The prognosis and treatment response of gliomas originated from different cell type may be significantly different. Therefore, it is necessary to study the origin cells of glioma