中文摘要：

Nesfatin-1是由核组蛋白2（NUCB2）衍生而来的肽段,是一种由下丘脑和外周组织表达的厌食信号肽,通过使动物产生饱腹感而抑制动物摄食。研究者发现,Nesfatin-1除了通过抑制动物摄食调节机体内稳态与能量储备,还参与初情启动和胰岛素抵抗等多种生理过程,具有多种生物学功能,本文综述了Nesfatin-1/NUCB2的分子生物学特征、功能及其基因表达的营养调控。

英文摘要：

Nesfatin-1 is a peptide fragment driven from nucleobindin 2（ NUCB2） in hypothalamus and peripheral tissues,and inhibit animal feed intake by satiety. Researchers found that Nesfatin-1 not only modified the whole-body homeostasis and energy storage through inhibiting feed intake,but also played roles in many physiological processes such as regulating puberty onset and insulin resistance and so on,with a variety of biological functions. This article reviewed the molecular biological characteristics,functions and nutritional regulation in gene expression of Nesfatin-1 / NUCB2.