目的探讨侵袭性肺部真菌感染(invasivepulmonaryfungalinfection,IPFI)的CT表现,以提高对该病的认识。方法回顾性分析117例经l临床证实的侵袭性肺部真菌感染的CT表现,按免疫状态进行分组,并采用7。或Fisher确切概率法对CT征象进行组间比较。结果IPFI最常见的CT表现为单发或多发结节或肿块影。共88例(75.2%),其次为肺气腔实变59例(50.4%)及磨玻璃影34例(29.1%),结节倾向于分布在肺外周带(P=0.003),实变倾向分布于下肺(P=0.013),3种病变在肺部单侧或双侧分布的比较无显著性差异(P=0.085)。AIDS患者结节中空洞的发生率(89.3%)显著高于非AIDS免疫抑制者(47.0%,P=0.000),免疫抑制患者的实变影中多发病灶的比率(75%)显著高于免疫正常者(28.6%。P=0.023)。结论IPFI以多发结节、实变为最常见的CT表现,不同免疫状态下IPFI的CT表现存在差异。
Objective To investigate CT features of invasive pulmonary fungal infection (IPFI), in order to improve the identifi- cation of this disease. Methods CT findings of IPFI clinically proved in 117 cases were retrospectively reviewed. Different patterns of CT findings between immunosuppressed and immunocompetent patients, AIDS and non AIDS immunosuppressed patients were compared by using Z2 or Fisher's exact test. Results The most common CT findings of IPFI were solitary or multiple nodules or mass which found in 88 cases (75.2%), followed by airspace consolidation in 59 cases (50.4%) and ground glass opacity(GGO) in 34 patients (29.1 %). Nodules tended to distributed in lung peripheral zone (P=0. 003}, while airspace consolidation tended to lo- cate in lower lung (P= 0. 013). There were no significant differences in unilateral or bilateral distribution between three type of the lesions (P= 0. 085). Cavitations within nodules/masses were more frequently present in AIDS patients(89.3 %) than those in non- AIDS immunosuppressed patients (47.0%, P= 0. 000). The rate of multiple lesions in airspace consolidation was significantly higher in immunosuppressed patients( 75 % ) than those in immunocompetent patients ( 28.6%, P= 0. 023 }. Conclusion The most common CT findings of IPFI are solitary or multiple nodules or mass, which in the patients with different immune status are of statistical differences.