中文摘要：

喷雾冷冻干燥技术是一种新型的难溶性药物微粒化技术方法,能制备出低密度、高比表面积的粒子,可用于改善难溶性药物的溶出度和生物利用度等。本文简介了喷雾冷冻干燥技术的原理、特点和应用,重点论述该技术影响药物微粒化的关键因素。

英文摘要：

Spray freeze drying （SFD） is a novel technology for micronization of poorly soluble drugs. This technology can be used to prepare the particles with low-density and high specific surface area, which are useful to improve the solubility and bioavailability of poorly soluble drugs. The principle, characteristics and applications of SFD are introduced in this paper. Special emphasis is placed on the key influence factors of SFD on micronization.