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中文摘要：
利用紫外吸收光谱法考察了八元瓜环（Q[8]）与抗癌药物甲氨蝶呤（MTX）的相互作用；同时研究了甲氨蝶呤的不同质子化形式及体系温度对相互作用的影响；计算了相应的稳定常数及热力学参数等．实验结果表明，Q[8]与MTX作用比为1：1，包结平衡常数为（7．64±1．52）×10^4L／mol；龄前热力学参数测定结果表明，上述主-客体的相互作用是自发进行的，且疏水作用力是反应的主要驱动力．采用^1H NMR法进一步证实了主-客体的作用模式．
英文摘要：
Cucurbit[ n ] urils（ Q [ n ] ） which have the unique structure with hydrophobic central cavity and hydrophilic carbonyl group portals, are a class of molecular containers that bind to a variety of cationic and neutral species with high affinity and therefore show great promise as a drug delivery system. In this paper, interactions of cucurbit[8] uril（ Q[8] ） with anti-cancer drug MTX in different proton forms were studied in details by UV absorption spectroscopy. The result shows that the inclusion ratio of Q [ 8 ] and MTX is 1： 1, and the formation constant is （7.64 ± 1.52） × 10^4 L/mol. Moreover, the thermodynamic parameters of the complex formation were also determined, and it shows that the formation of the inclusion complexes between MTX and Q [ 8 ] is entropy controlled, suggesting that hydrophobic forces are the main driving forces. The inclusion complex was further proved by ^1H NMR.
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